Ingredients

Clinical Evidence

Hovenia dulcis (dihydromyricetin) is listed among the premier anti-hangover herbal medicines in China’s first pharmacopoeia, Tang Materia Medica. Hovenia extracts ameliorate alcohol-induced liver injuries (Du et al., 2010), and relieve hangover, partly by promoting EtOH elimination via enhancement of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activity (Kim et al., 2000; Chen et al., 2006). However, its true efficacy, active constituents, and mechanisms of action have not been critically examined.

Here we demonstrate that dihydromyricetin (DHM), a flavonoid component from Hovenia, is highly effective in counteracting acute EtOH intoxication, EtOH exposure/withdrawal-induced GABAAR plasticity and AWS symptoms, as well as reducing excessive EtOH consumption. We provide strong evidence that DHM is a candidate for development as a novel AUD therapy.

PMC Information Link

Dihydromyricetin prevents fetal alcohol exposure-induced behavioral and physiological deficits: the roles of GABAA receptors in adolescence.

Pubmed Information Link

Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression

World Journal of Gastroenterology Link

Core tip: The novel findings of this report are that dihydromyricetin (DHM) can strongly inhibit the migration and invasion (in transwell experiments) of the hepatic cancer cell lines SK-Hep-1 and MHCC97L. Western blot analysis showed that DHM down-regulated the level of matrix metalloproteinase 9 (MMP-9) protein but had little effect on the expression of MMP-2. Further investigation indicated that this reduction of MMP-9 expression underlies the inhibitory effects of DHM on cell migration and invasion and that this decrease was associated with an increase in the total protein levels of PKC-δ and decrease in the protein phosphorylation levels of members of the MAPK signaling pathway.

Electrolyte and Vitamin Combo

World Health Organization ORS:

WHO Drug Information Link

“The B-complex vitamins are especially vulnerable and destroyed by alcohol. These vitamins are essential to mental and emotional well-being. “

  • Vitamin B1 (thiamin)- deficiencies trigger depression and irritability and can cause neurological and cardiac disorders among alcoholics.
  • Vitamin B2 (riboflavin)- In 1982 an article published in the British Journal of Psychiatry reported that every one of 172 successive patients admitted to a British psychiatric hospital for treatment for depression was deficient in B2.
  • Vitamin B3 (niacin)- depletion causes anxiety, depression, apprehension and fatigue.
  • Pantothenic acid- symptoms of deficiency are fatigue, chronic stress and depression.
  • Vitamin B6 (pyridoxine)- deficiencies can disrupt the formation of neurotransmitters.
  • Vitamin B12– deficiency will cause depression.
  • Folic Acid- deficiency is a common cause of depression.

https://www.bouldermedicalcenter.com/

Capsule Contents:

White Willow Bark Extract and Caffeine for headaches.

Willow Bark is Nature’s Aspirin

http://www.webmd.com/vitamins-supplements/

Same amount of Caffeine as a cup of coffee. Caffeine helps with headaches and natural diuretic to flush out toxins after re-hydrating.

Clinical References

1.

Reduced Osmolarity

2.

Vitamins Reference

“The B-complex vitamins are especially vulnerable and destroyed by alcohol. These vitamins are essential to mental and emotional well-being. “

Vitamin B1 (thiamin)- deficiencies trigger depression and irritability and can cause neurological and cardiac disorders among alcoholics.

Vitamin B2 (riboflavin)- In 1982 an article published in the British Journal of Psychiatry reported that every one of 172 successive patients admitted to a British psychiatric hospital for treatment for depression was deficient in B2.

Vitamin B3 (niacin)- depletion causes anxiety, depression, apprehension and fatigue.

Pantothenic acid- symptoms of deficiency are fatigue, chronic stress and depression.

Vitamin B6 (pyridoxine)- deficiencies can disrupt the formation of neurotransmitters.

Vitamin B12– deficiency will cause depression.

Folic Acid- deficiency is a common cause of depression.

Welcome to Boulder Medical Center

3.

Dihydromyricetin Reference

DHM speeds up the body’s ability to metabolize alcohol and acetaldehyde, a toxic byproduct of alcohol consumption

This allows your liver to resume its normal function more quickly and lessens the damage alcohol consumption causes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/

DHM reduces the effect alcohol has on the brain’s GABA receptors

Research has shown Dihydromyricetin (DHM) to be an anti-oxidant and help protect the brain from damage caused by excessive alcohol consumption.

http://www.sciencedirect.com/science/article/pii/S221345301200002X

 

More reading on DHM

  1. Dihydromyricetin As A Novel Anti-Alcohol Intoxication Medication

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/

  1. Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking

https://www.ncbi.nlm.nih.gov/pubmed/17048612/

  1. Pharmacological potential of ampelopsin (DHM) in Rattan tea

http://www.sciencedirect.com/science/article/pii/S221345301200002X

4.

Protection against Acetaldehyde Toxicity

  1. Protection against Acetaldehyde Toxicity in the rat byl-cysteine, thiamin andl-2-Methylthiazolidine-4-carboxylic acid. Supported by US Veterans Administration (Project Nos. 8078-01 and [8078] 2-70).

https://rd.springer.com/article/10.1007%2FBF01966822#page-1

More detailed Info from:

https://dhmdepot.com/pages/dihydromyricetin-prevents-hangovers#

Artichoke extract:

Artichoke is used to stimulate the flow of bile from the liver, and this is thought to help reduce the symptoms of heartburn and alcohol “hangover.”

http://www.webmd.com/vitamins-supplements/ingredientmono-842-artichoke.aspx?activeingredientid=842

White Willow Bark Extract and Caffeine help soothe headaches.

Willow Bark is Nature’s Aspirin

http://www.webmd.com/vitamins-supplements/

Same amount of Caffeine as a cup of coffee, not too much. Caffeine helps with headaches and natural diuretic to flush out toxins after re-hydrating.

http://www.webmd.com/migraines-headaches/guide/triggers-caffeine#1

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"These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cruse or prevent any disease."

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